Use antivirus software. While there's not a catch-all solution, and antivirus software won't protect against sophisticated and cutting-edge keyloggers, there's still no excuse for not using antivirus software which protects against most known keylogger software.
Use on-screen keyboards when entering passwords. One of the limitations of most keyloggers is that they only capture actual keystrokes being pressed on the keyboard. The Windows on-screen keyboard will provide a virtual keyboard that may help circumvent keyloggers.
Use a firewall. It's possible lazy attackers won't go through the effort of disguising their payloads to appear as being normal DNS (port 53) or HTTP (port 80) transmissions. A firewall might catch suspicious packets leaving your computer on port 35357.
Protect your computer against backdoors. While all of the above is helpful when you're already backdoored, the best thing to do is make sure you're not exploited in the first place
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